University of Idaho
BYU-Idaho Chemistry department welcomes Patrick Hrdlicka to Campus. Dr. Hrdlicka will be coming on Campus to present a seminar to the Chemistry department about the current research that he is doing at U of I. He will also bring with him his vast knowledge of what U of I has to offer graduating BYU-I chemistry students. The title of his seminar is "Recognition of double-stranded DNA using energetically activated duplexes - molecular tools for revealing the genome".
Abstract: Development of synthetic ligands capable of decoding the sequence information of double-stranded DNA (dsDNA) has proven very challenging since Watson-Crick base pairs are buried deeply within the duplex core and not readily accessible for information readout by exogenous ligands. State-of-the-art dsDNA-targeting agents, i.e., polyamides, engineered proteins, and triplex-forming oligonucleotides or peptide nucleic acids (PNAs), therefore recognize chemical features that are accessible via one of the duplex grooves instead. While these strategies are attractive, they are not without limitations, which is regrettable since reliable dsDNA-recognition technologies can provide access to new classes of therapeutic and diagnostic agents and tools for studying genomes. In this presentation, I will introduce a unique strategy for dsDNA-recognition, i.e., the use of double-stranded oligonucleotide probes, which are activated for dsDNA-recognition through modification with interstrand zipper arrangements of intercalator-functionalized nucleotides. I will present results from biological recognition experiments, which demonstrate that previously inaccessible DNA targets may become accessible to exogenous control, which has exciting prospects for karyotyping, in vivo imaging and gene regulation.
Please join us for an exciting seminar on Nov. 20, 2014 at 2:00 pm in ROM 299.
Refreshments will be served.
- Available For Fall